Nature of Functional Estrogen Receptors at the Plasma Membrane
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چکیده
منابع مشابه
Nature of functional estrogen receptors at the plasma membrane.
Although rapid signaling by estrogen at the plasma membrane is established, it is controversial as to the nature of the receptor protein. Estrogen may bind membrane proteins comparable to classical nuclear estrogen receptors (ERs), but some studies identify nonclassical receptors, such as G protein-coupled receptor (GPR)30. We took several approaches to define membrane-localized estrogen-bindin...
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A series of emerging data supports the existence and importance of plasma membrane localized estrogen receptors in a variety of cells that are targets for the steroid hormone action. When estradiol (E2) binds to the cell surface protein, the ensuing signal transduction event triggers downstream signaling cascades that contribute to important biological functions. Aside from the classical signal...
متن کاملPlasma membrane estrogen receptors exist and functions as dimers.
A small pool of estrogen receptors (ERalpha and -beta) localize at the plasma membrane and rapidly signal to affect cellular physiology. Although nuclear ERs function mainly as homodimers, it is unknown whether membrane-localized ER exists or functions with similar requirements. We report that the endogenous ER isoforms at the plasma membrane of breast cancer or endothelial cells exist predomin...
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15 صفحه اولPlasma membrane receptors.
Receptors are macromolecules in or on cells that mediate physiological responses upon binding specific li-gands. Over the past few years, important advances have been made in the understanding of the biology of receptors, both at a basic and at a clinical level. Receptors bind their ligands with remarkable selectiv-ity and with high affinity, permitting a given physiological response to be elic...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2006
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2005-0525